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multilamellar body中文是什么意思

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  • We also investigated the pathological changes of mouse liver , thymus and cerebrum cortex challenged by so2 inhalation by in vivo tests . we studied the apoptotic induction on mouse spleen cells and cytotoxicity of human embryo lung fibroblasts of so2 derivatives by in vitro tests . in vivo tests of sulfur dioxide inhalation showed : ( 1 ) effects on mouse lung of so2 challenge : we found no significant apoptotic changes induced by so2 inhalation but obvious pathological changes of lung with vacuolating of osmiophilic multilamellar bodies which maybe related with the decrease of surfacant and decrease of microvillus of type ii alveolar cells ; we also found thickening of part of basement lamina between type i alveolar cells and capillary endothelium cells which may inhibit the dispersion of oxygen and contribute to lung dysfunction
    二氧化硫熏氣染毒的體內(nèi)實(shí)驗(yàn)結(jié)果表明,在本次實(shí)驗(yàn)的濃度范圍內(nèi)( 56mg m ~ 3 、 112mg m ~ 3 、 168mg m ~ 3低、中、高三個(gè)濃度) : ( 1 )通過(guò)透射電鏡、 dna凝膠電泳分析和流式細(xì)胞分析發(fā)現(xiàn)二氧化硫吸入染毒一周對(duì)小鼠肺臟沒有明顯的凋亡誘導(dǎo)作用,但通過(guò)透射電鏡觀察發(fā)現(xiàn)二氧化硫可引起肺臟明顯的超微結(jié)構(gòu)改變,引起型肺泡上皮細(xì)胞板層體空泡化,微絨毛減少,線粒體致密化或腫脹變性;肺泡血管內(nèi)皮細(xì)胞和型肺泡上皮細(xì)胞之間基膜增厚,使氧氣彌散功能出現(xiàn)障礙,從而降低肺功能。
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